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RRAS2

GENERAL INFORMATION

Gene name

 RRAS2

Gene description

 Related RAS viral (r-ras) oncogene homolog 2

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA050942 , CAB010420
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), liver cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Liver cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050942
CAB010420

GENE INFORMATION

Gene name

 RRAS2 (HGNC Symbol)

Synonyms

 TC21

Description

 Related RAS viral (r-ras) oncogene homolog 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Chromosome

 11

Cytoband

 p15.2

Chromosome location (bp)

 14277926 - 14364506

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000133818 (version 83.38)

Entrez gene

 22800

UniProt

 P62070 (UniProt - Evidence at protein level)

neXtProt

 NX_P62070

Antibodypedia

 RRAS2 antibodies

PROTEIN BROWSER
RRAS2-001
RRAS2-003
RRAS2-004
RRAS2-005
RRAS2-006
RRAS2-007
RRAS2-008
RRAS2-012
RRAS2-201
RRAS2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRAS2-001
ENSP00000256196
ENST00000256196
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0009987 [cellular process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030335 [positive regulation of cell migration]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 204 aa
23.4 kDa 		No 0
RRAS2-003
ENSP00000431954
ENST00000532814
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 127 aa
15.1 kDa 		No 0
RRAS2-004
ENSP00000434104
ENST00000526063
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 127 aa
15.1 kDa 		No 0
RRAS2-005
ENSP00000437083
ENST00000534746
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 127 aa
15.1 kDa 		No 0
RRAS2-006
ENSP00000403282
ENST00000414023
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 127 aa
15.1 kDa 		No 0
RRAS2-007
ENSP00000435453
ENST00000531807
E9PK85 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 166 aa
19.6 kDa 		No 0
RRAS2-008
ENSP00000433230
ENST00000529237
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 127 aa
15.1 kDa 		No 0
RRAS2-012
ENSP00000432559
ENST00000531421
E9PQ87 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 69 aa
8.2 kDa 		No 0
RRAS2-201
ENSP00000437547
ENST00000537760
P62070 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0070062 [extracellular exosome]
GO:1901214 [regulation of neuron death]
Show all
 169 aa
19.8 kDa 		No 0
RRAS2-202
ENSP00000441722
ENST00000545643
A0A0C4DGH2 [Direct mapping]
Ras-related protein R-Ras2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 203 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.