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BHLHE40

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GENERAL INFORMATION

Gene name

 BHLHE40

Gene description

 Basic helix-loop-helix family, member e40

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear bodies.

RNA cell category

 Cell line enhanced (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA028922
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear bodies.

Main location

 Nuclear bodies (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA028922 A-431 Nuclear bodies
HPA028922 U-2 OS No staining    
HPA028922 U-251 MG Nuclear bodies

GENE INFORMATION

Gene name

 BHLHE40 (HGNC Symbol)

Synonyms

 BHLHB2, bHLHe40, DEC1, STRA13

Description

 Basic helix-loop-helix family, member e40 (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Chromosome

 3

Cytoband

 p26.1

Chromosome location (bp)

 4979116 - 4985323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134107 (version 83.38)

Entrez gene

 8553

UniProt

 O14503 (UniProt - Evidence at protein level)

neXtProt

 NX_O14503

Antibodypedia

 BHLHE40 antibodies

PROTEIN BROWSER
BHLHE40-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BHLHE40-001
ENSP00000256495
ENST00000256495
O14503 [Direct mapping]
Class E basic helix-loop-helix protein 40
Q6IB83 [Target identity:100%; Query identity:100%]
BHLHB2 protein; Basic helix-loop-helix domain containing, class B, 2, isoform CRA_a; Basic helix-loop-helix domain-containing; cDNA, FLJ92873, Homo sapiens basic helix-loop-helix domain containing, class B, 2(BHLHB2), mRNA
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009416 [response to light stimulus]
GO:0019904 [protein domain specific binding]
GO:0032922 [circadian regulation of gene expression]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043425 [bHLH transcription factor binding]
GO:0043426 [MRF binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
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 412 aa
45.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.