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BHLHE40

GENERAL INFORMATION

Gene name

 BHLHE40

Gene description

 Basic helix-loop-helix family, member e40

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA028922
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028922

GENE INFORMATION

Gene name

 BHLHE40 (HGNC Symbol)

Synonyms

 BHLHB2, bHLHe40, DEC1, STRA13

Description

 Basic helix-loop-helix family, member e40 (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014]

Chromosome

 3

Cytoband

 p26.1

Chromosome location (bp)

 4979116 - 4985323

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134107 (version 83.38)

Entrez gene

 8553

UniProt

 O14503 (UniProt - Evidence at protein level)

neXtProt

 NX_O14503

Antibodypedia

 BHLHE40 antibodies

PROTEIN BROWSER
BHLHE40-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BHLHE40-001
ENSP00000256495
ENST00000256495
O14503 [Direct mapping]
Class E basic helix-loop-helix protein 40
Q6IB83 [Target identity:100%; Query identity:100%]
BHLHB2 protein; Basic helix-loop-helix domain containing, class B, 2, isoform CRA_a; Basic helix-loop-helix domain-containing; cDNA, FLJ92873, Homo sapiens basic helix-loop-helix domain containing, class B, 2(BHLHB2), mRNA
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001191 [transcriptional repressor activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009416 [response to light stimulus]
GO:0019904 [protein domain specific binding]
GO:0032922 [circadian regulation of gene expression]
GO:0042803 [protein homodimerization activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043425 [bHLH transcription factor binding]
GO:0043426 [MRF binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
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 412 aa
45.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.