Expression of TRPM1 in cancer - Summary - The Human Protein Atlas

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TRPM1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRPM1
Gene description	Transient receptor potential cation channel, subfamily M, member 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Group enriched (skin, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in outer plexiform layer and inner nuclear layer in retina.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Approved based on 1 antibody. HPA014779
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014779

GENE INFORMATION
Gene name	TRPM1 (HGNC Symbol)
Synonyms	CSNB1C, LTRPC1, MLSN1
Description	Transient receptor potential cation channel, subfamily M, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Chromosome	15
Cytoband	q13.3
Chromosome location (bp)	31001061 - 31161273
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134160 (version 83.38)
Entrez gene	4308
UniProt	Q7Z4N2 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4N2
Antibodypedia	TRPM1 antibodies

PROTEIN BROWSER

TRPM1-001	TRPM1-002	TRPM1-003	TRPM1-004	TRPM1-007	TRPM1-008	TRPM1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM1-001 ENSP00000380897 ENST00000397795	Q7Z4N2 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070588 [calcium ion transmembrane transport] GO:0071482 [cellular response to light stimulus] Show all	1603 aa 182.2 kDa	No	8
TRPM1-002 ENSP00000453477 ENST00000559177	H0YM61 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005261 [cation channel activity] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0071482 [cellular response to light stimulus] GO:0098655 [cation transmembrane transport] Show all	505 aa 57.4 kDa	No	2
TRPM1-003 ENSP00000453851 ENST00000559179	Q7Z4N2 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0005262 [calcium channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070588 [calcium ion transmembrane transport] GO:0071482 [cellular response to light stimulus] Show all	136 aa 15.1 kDa	No	0
TRPM1-004 ENSP00000256552 ENST00000256552	Q7Z4N2 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070588 [calcium ion transmembrane transport] GO:0071482 [cellular response to light stimulus] Show all	1625 aa 184.8 kDa	No	7
TRPM1-007 ENSP00000453119 ENST00000558768	A0A0A0MTQ9 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0006811 [ion transport] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071482 [cellular response to light stimulus] GO:0098655 [cation transmembrane transport] Show all	1526 aa 173.6 kDa	No	7
TRPM1-008 ENSP00000452946 ENST00000558445	H0YKU7 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0006811 [ion transport] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071482 [cellular response to light stimulus] GO:0098655 [cation transmembrane transport] Show all	1390 aa 158.4 kDa	No	8
TRPM1-201 ENSP00000437849 ENST00000542188	Q7Z4N2 [Direct mapping] Transient receptor potential cation channel subfamily M member 1 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007216 [G-protein coupled glutamate receptor signaling pathway] GO:0007601 [visual perception] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0035841 [new growing cell tip] GO:0046548 [retinal rod cell development] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070588 [calcium ion transmembrane transport] GO:0071482 [cellular response to light stimulus] GO:0098655 [cation transmembrane transport] Show all	1642 aa 186.5 kDa	No	8

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