Expression of CHIA in cancer - Summary - The Human Protein Atlas

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CHIA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHIA
Gene description	Chitinase, acidic
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (lung cancer, stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (lung, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA059193
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (lung cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059193

GENE INFORMATION
Gene name	CHIA (HGNC Symbol)
Synonyms	AMCase, CHIT2, TSA1902
Description	Chitinase, acidic (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	111290862 - 111320566
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134216 (version 83.38)
Entrez gene	27159
UniProt	Q9BZP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZP6
Antibodypedia	CHIA antibodies

PROTEIN BROWSER

CHIA-001	CHIA-002	CHIA-004	CHIA-005	CHIA-006	CHIA-008	CHIA-201	CHIA-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHIA-001 ENSP00000358755 ENST00000369740	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	476 aa 52.3 kDa	Yes	0
CHIA-002 ENSP00000391132 ENST00000430615	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	368 aa 40.1 kDa	No	0
CHIA-004 ENSP00000433309 ENST00000489524	E9PLJ2 [Direct mapping] Acidic mammalian chitinase Show all	Predicted intracellular proteins Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] Show all	287 aa 30.8 kDa	No	0
CHIA-005 ENSP00000387671 ENST00000422815	Q5VUV5 [Direct mapping] Acidic mammalian chitinase Show all	Predicted intracellular proteins Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	420 aa 45.5 kDa	No	0
CHIA-006 ENSP00000436946 ENST00000483391	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	315 aa 33.9 kDa	No	0
CHIA-008 ENSP00000338970 ENST00000353665	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	315 aa 33.9 kDa	No	0
CHIA-201 ENSP00000341828 ENST00000343320	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	476 aa 52.3 kDa	Yes	0
CHIA-202 ENSP00000390476 ENST00000451398	Q9BZP6 [Direct mapping] Acidic mammalian chitinase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0000272 [polysaccharide catabolic process] GO:0002532 [production of molecular mediator involved in inflammatory response] GO:0003796 [lysozyme activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006030 [chitin metabolic process] GO:0006032 [chitin catabolic process] GO:0006037 [cell wall chitin metabolic process] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0007586 [digestion] GO:0008061 [chitin binding] GO:0009620 [response to fungus] GO:0019900 [kinase binding] GO:0030246 [carbohydrate binding] GO:0090197 [positive regulation of chemokine secretion] Show all	315 aa 33.9 kDa	No	0

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The Human Protein Atlas

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