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CHIA

GENERAL INFORMATION

Gene name

 CHIA

Gene description

 Chitinase, acidic

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (lung, stomach)
GTEx:Tissue enriched (stomach)
FANTOM5:Tissue enhanced (lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA059193
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION

Gene name

 CHIA (HGNC Symbol)

Synonyms

 AMCase, CHIT2, TSA1902

Description

 Chitinase, acidic (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 1

Cytoband

 p13.2

Chromosome location (bp)

 111290862 - 111320566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134216 (version 83.38)

Entrez gene

 27159

UniProt

 Q9BZP6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZP6

Antibodypedia

 CHIA antibodies

PROTEIN BROWSER
CHIA-001
CHIA-002
CHIA-004
CHIA-005
CHIA-006
CHIA-008
CHIA-201
CHIA-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHIA-001
ENSP00000358755
ENST00000369740
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 476 aa
52.3 kDa 		Yes 0
CHIA-002
ENSP00000391132
ENST00000430615
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 368 aa
40.1 kDa 		No 0
CHIA-004
ENSP00000433309
ENST00000489524
E9PLJ2 [Direct mapping]
Acidic mammalian chitinase
Show all
Predicted intracellular proteins
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006032 [chitin catabolic process]
Show all
 287 aa
30.8 kDa 		No 0
CHIA-005
ENSP00000387671
ENST00000422815
Q5VUV5 [Direct mapping]
Acidic mammalian chitinase
Show all
Predicted intracellular proteins
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0008061 [chitin binding]
Show all
 420 aa
45.5 kDa 		No 0
CHIA-006
ENSP00000436946
ENST00000483391
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 315 aa
33.9 kDa 		No 0
CHIA-008
ENSP00000338970
ENST00000353665
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 315 aa
33.9 kDa 		No 0
CHIA-201
ENSP00000341828
ENST00000343320
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 476 aa
52.3 kDa 		Yes 0
CHIA-202
ENSP00000390476
ENST00000451398
Q9BZP6 [Direct mapping]
Acidic mammalian chitinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0000272 [polysaccharide catabolic process]
GO:0002532 [production of molecular mediator involved in inflammatory response]
GO:0003796 [lysozyme activity]
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004568 [chitinase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0006030 [chitin metabolic process]
GO:0006032 [chitin catabolic process]
GO:0006037 [cell wall chitin metabolic process]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0007586 [digestion]
GO:0008061 [chitin binding]
GO:0009620 [response to fungus]
GO:0019900 [kinase binding]
GO:0030246 [carbohydrate binding]
GO:0090197 [positive regulation of chemokine secretion]
Show all
 315 aa
33.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.