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NAPG

GENERAL INFORMATION

Gene name

 NAPG

Gene description

 N-ethylmaleimide-sensitive factor attachment protein, gamma

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA008208 , HPA011389
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA008208
HPA011389

GENE INFORMATION

Gene name

 NAPG

Synonyms

Description

 N-ethylmaleimide-sensitive factor attachment protein, gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

Chromosome

 18

Cytoband

 p11.22

Chromosome location (bp)

 10525905 - 10552761

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134265 (version 83.38)

Entrez gene

 8774

UniProt

 Q99747 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99747

Antibodypedia

 NAPG antibodies

PROTEIN BROWSER
NAPG-001
NAPG-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NAPG-001
ENSP00000324628
ENST00000322897
Q99747 [Direct mapping]
Gamma-soluble NSF attachment protein
Q6FHY4 [Target identity:100%; Query identity:100%]
N-ethylmaleimide-sensitive factor attachment protein, gamma, isoform CRA_b; NAPG protein; cDNA, FLJ95310, Homo sapiens N-ethylmaleimide-sensitive factor attachment protein,gamma (NAPG), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005483 [soluble NSF attachment protein activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0006461 [protein complex assembly]
GO:0006886 [intracellular protein transport]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0043209 [myelin sheath]
GO:0050821 [protein stabilization]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
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 312 aa
34.7 kDa 		No 0
NAPG-006
ENSP00000463018
ENST00000582472
J3KTJ6 [Direct mapping]
Gamma-soluble NSF attachment protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005483 [soluble NSF attachment protein activity]
GO:0006886 [intracellular protein transport]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
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 177 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.