Expression of GRHL1 in cancer - Summary

GENERAL INFORMATION
Gene name	GRHL1
Gene description	Grainyhead-like transcription factor 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, SK-BR-3)
HPA (normal tissue):	Tissue enhanced (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues, including nuclear expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA005798 , HPA006420
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005798	HPA006420

GENE INFORMATION
Gene name	GRHL1 (HGNC Symbol)
Synonyms	LBP-32, MGR, TFCP2L2
Description	Grainyhead-like transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	9951693 - 10002277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134317 (version 83.38)
Entrez gene	29841
UniProt	Q9NZI5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZI5
Antibodypedia	GRHL1 antibodies

PROTEIN BROWSER

GRHL1-001	GRHL1-005	GRHL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRHL1-001 ENSP00000324693 ENST00000324907	Q9NZI5 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	618 aa 70.1 kDa	No	0
GRHL1-005 ENSP00000419831 ENST00000480736	C9JYY8 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.2 kDa	No	0
GRHL1-201 ENSP00000384209 ENST00000405379	Q9NZI5 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	429 aa 49.2 kDa	No	0