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GRHL1

GENERAL INFORMATION

Gene name

 GRHL1

Gene description

 Grainyhead-like transcription factor 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin, vagina)
FANTOM5:Tissue enhanced (esophagus, placenta, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues, including nuclear expression in squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA005798 , HPA006420
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, placenta, tonsil)

GENE INFORMATION

Gene name

 GRHL1 (HGNC Symbol)

Synonyms

 LBP-32, MGR, TFCP2L2

Description

 Grainyhead-like transcription factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 9951693 - 10002277

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134317 (version 83.38)

Entrez gene

 29841

UniProt

 Q9NZI5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZI5

Antibodypedia

 GRHL1 antibodies

PROTEIN BROWSER
GRHL1-001
GRHL1-005
GRHL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRHL1-001
ENSP00000324693
ENST00000324907
Q9NZI5 [Direct mapping]
Grainyhead-like protein 1 homolog
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0031490 [chromatin DNA binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 618 aa
70.1 kDa 		No 0
GRHL1-005
ENSP00000419831
ENST00000480736
C9JYY8 [Direct mapping]
Grainyhead-like protein 1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 72 aa
8.2 kDa 		No 0
GRHL1-201
ENSP00000384209
ENST00000405379
Q9NZI5 [Direct mapping]
Grainyhead-like protein 1 homolog
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   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0031490 [chromatin DNA binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 429 aa
49.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.