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Colorectal cancers showed strong cytoplasmic staining. Cancer cells in general showed weak to moderate immunoreactivity. Several renal cancers were negative.
Most cancer tissues showed weak to moderate cytoplasmic staining. Lymphomas and most renal cancers were negative.
GENE INFORMATION
Gene name
ROCK2
Synonyms
Description
Rho-associated, coiled-coil containing protein kinase 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
O75116 [Direct mapping] Rho-associated protein kinase 2
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000910 [cytokinesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006939 [smooth muscle contraction] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007411 [axon guidance] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016525 [negative regulation of angiogenesis] GO:0017048 [Rho GTPase binding] GO:0017049 [GTP-Rho binding] GO:0030036 [actin cytoskeleton organization] GO:0030155 [regulation of cell adhesion] GO:0030866 [cortical actin cytoskeleton organization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0042752 [regulation of circadian rhythm] GO:0044822 [poly(A) RNA binding] GO:0045616 [regulation of keratinocyte differentiation] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048511 [rhythmic process] GO:0051298 [centrosome duplication] GO:0051492 [regulation of stress fiber assembly] GO:0051893 [regulation of focal adhesion assembly] GO:0071394 [cellular response to testosterone stimulus] GO:0072518 [Rho-dependent protein serine/threonine kinase activity] GO:0090002 [establishment of protein localization to plasma membrane] GO:1903140 [regulation of establishment of endothelial barrier] GO:1903347 [negative regulation of bicellular tight junction assembly] GO:2000114 [regulation of establishment of cell polarity] GO:2000145 [regulation of cell motility]