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Rho-associated, coiled-coil containing protein kinase 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
O75116 [Direct mapping] Rho-associated protein kinase 2
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000910 [cytokinesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006939 [smooth muscle contraction] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007411 [axon guidance] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0016525 [negative regulation of angiogenesis] GO:0017048 [Rho GTPase binding] GO:0017049 [GTP-Rho binding] GO:0030036 [actin cytoskeleton organization] GO:0030155 [regulation of cell adhesion] GO:0030866 [cortical actin cytoskeleton organization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0042752 [regulation of circadian rhythm] GO:0044822 [poly(A) RNA binding] GO:0045616 [regulation of keratinocyte differentiation] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048511 [rhythmic process] GO:0051298 [centrosome duplication] GO:0051492 [regulation of stress fiber assembly] GO:0051893 [regulation of focal adhesion assembly] GO:0071394 [cellular response to testosterone stimulus] GO:0072518 [Rho-dependent protein serine/threonine kinase activity] GO:0090002 [establishment of protein localization to plasma membrane] GO:1903140 [regulation of establishment of endothelial barrier] GO:1903347 [negative regulation of bicellular tight junction assembly] GO:2000114 [regulation of establishment of cell polarity] GO:2000145 [regulation of cell motility]