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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDC73
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDC73

Gene description

Cell division cycle 73

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB016359
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB016359

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant lymphomas and cholangiocarcinomas showed moderate to strong nuclear staining in most cases. Other malignancies showed a few cases moderate to strong staning.

GENE INFORMATION

Gene name

CDC73 (HGNC Symbol)

Synonyms

C1orf28, FIHP, HRPT1, HRPT2, parafibromin

Description

Cell division cycle 73 (HGNC Symbol)

Entrez gene summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

Chromosome

1

Cytoband

q31.2

Chromosome location (bp)

193122017 - 193253901

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134371 (version 83.38)

Entrez gene

79577

UniProt

Q6P1J9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6P1J9

Antibodypedia

CDC73 antibodies

PROTEIN BROWSER

CDC73-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDC73-001
ENSP00000356405
ENST00000367435
Q6P1J9 [Direct mapping]
Parafibromin
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000993 [RNA polymerase II core binding]
GO:0001711 [endodermal cell fate commitment]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006378 [mRNA polyadenylation]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell proliferation]
GO:0010390 [histone monoubiquitination]
GO:0016055 [Wnt signaling pathway]
GO:0016593 [Cdc73/Paf1 complex]
GO:0019827 [stem cell population maintenance]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0031648 [protein destabilization]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0033523 [histone H2B ubiquitination]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
531 aa
60.6 kDa
No 0

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