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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDC73
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CDC73

Gene description

Cell division cycle 73

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
CAB016359
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CDC73 (HGNC Symbol)

Synonyms

C1orf28, FIHP, HRPT1, HRPT2, parafibromin

Description

Cell division cycle 73 (HGNC Symbol)

Entrez gene summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

Chromosome

1

Cytoband

q31.2

Chromosome location (bp)

193122017 - 193253901

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134371 (version 83.38)

Entrez gene

79577

UniProt

Q6P1J9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6P1J9

Antibodypedia

CDC73 antibodies

PROTEIN BROWSER

CDC73-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDC73-001
ENSP00000356405
ENST00000367435
Q6P1J9 [Direct mapping]
Parafibromin
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Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000993 [RNA polymerase II core binding]
GO:0001711 [endodermal cell fate commitment]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006378 [mRNA polyadenylation]
GO:0007049 [cell cycle]
GO:0008285 [negative regulation of cell proliferation]
GO:0010390 [histone monoubiquitination]
GO:0016055 [Wnt signaling pathway]
GO:0016593 [Cdc73/Paf1 complex]
GO:0019827 [stem cell population maintenance]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0031648 [protein destabilization]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0033523 [histone H2B ubiquitination]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
531 aa
60.6 kDa
No 0

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