Expression of CRB1 in cancer - Summary - The Human Protein Atlas

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CRB1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRB1
Gene description	Crumbs family member 1, photoreceptor morphogenesis associated
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (HeLa)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in retina.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation.
Reliability score	Approved based on 2 antibodies. HPA061250 , HPA063127
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA061250	HPA063127

GENE INFORMATION
Gene name	CRB1 (HGNC Symbol)
Synonyms	LCA8, RP12
Description	Crumbs family member 1, photoreceptor morphogenesis associated (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	197268204 - 197478455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134376 (version 83.38)
Entrez gene	23418
UniProt	P82279 (UniProt - Evidence at protein level)
neXtProt	NX_P82279
Antibodypedia	CRB1 antibodies

PROTEIN BROWSER

CRB1-002	CRB1-003	CRB1-004	CRB1-005	CRB1-201	CRB1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRB1-002 ENSP00000395407 ENST00000448952	A0A0C4DG35 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	42 aa 4.6 kDa	No	0
CRB1-003 ENSP00000356367 ENST00000367397	A0A075B6G4 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	674 aa 74.7 kDa	No	0
CRB1-004 ENSP00000356370 ENST00000367400	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0007009 [plasma membrane organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0042462 [eye photoreceptor cell development] GO:0061024 [membrane organization] Show all	1406 aa 154.2 kDa	Yes	1
CRB1-005 ENSP00000356369 ENST00000367399	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] Show all	1294 aa 142.1 kDa	Yes	1
CRB1-201 ENSP00000438786 ENST00000535699	F5H0L2 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1382 aa 151.2 kDa	No	1
CRB1-202 ENSP00000438091 ENST00000538660	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] Show all	870 aa 95 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.