Expression of ECHDC3 in cancer - Summary - The Human Protein Atlas

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ECHDC3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ECHDC3
Gene description	Enoyl CoA hydratase domain containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, BEWO)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Luminal membranous staining in gastrointestinal tract observed as off target and disregarded.
Reliability score	Supported based on 1 antibody. HPA038306
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038306

GENE INFORMATION
Gene name	ECHDC3 (HGNC Symbol)
Synonyms	FLJ20909
Description	Enoyl CoA hydratase domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	p14
Chromosome location (bp)	11742366 - 11764070
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134463 (version 83.38)
Entrez gene	79746
UniProt	Q96DC8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DC8
Antibodypedia	ECHDC3 antibodies

PROTEIN BROWSER

ECHDC3-001	ECHDC3-004	ECHDC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECHDC3-001 ENSP00000368517 ENST00000379215	Q96DC8 [Direct mapping] Enoyl-CoA hydratase domain-containing protein 3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	303 aa 32.6 kDa	No	0
ECHDC3-004 ENSP00000405584 ENST00000420401	Q5W0J8 [Direct mapping] Enoyl-CoA hydratase domain-containing protein 3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	241 aa 25.4 kDa	No	0
ECHDC3-005 ENSP00000398429 ENST00000422887	Q5W0J6 [Direct mapping] Enoyl-CoA hydratase domain-containing protein 3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	166 aa 17.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.