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HRH4

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GENERAL INFORMATION

Gene name

 HRH4

Gene description

 Histamine receptor H4

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HL-60)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HL-60)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HRH4 (HGNC Symbol)

Synonyms

 AXOR35, GPCR105, GPRv53, H4R, HH4R

Description

 Histamine receptor H4 (HGNC Symbol)

Entrez gene summary

 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 24460629 - 24479957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134489 (version 83.38)

Entrez gene

 59340

UniProt

 Q9H3N8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3N8

Antibodypedia

 HRH4 antibodies

PROTEIN BROWSER
HRH4-001
HRH4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HRH4-001
ENSP00000256906
ENST00000256906
Q9H3N8 [Direct mapping]
Histamine H4 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0043408 [regulation of MAPK cascade]
GO:0051381 [histamine binding]
Show all
 390 aa
44.5 kDa 		No 7
HRH4-002
ENSP00000402526
ENST00000426880
Q9H3N8 [Direct mapping]
Histamine H4 receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004969 [histamine receptor activity]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008150 [biological_process]
GO:0016021 [integral component of membrane]
GO:0043408 [regulation of MAPK cascade]
GO:0051381 [histamine binding]
Show all
 302 aa
34.5 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.