Expression of HRH4 in cancer - Summary - The Human Protein Atlas

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HRH4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HRH4
Gene description	Histamine receptor H4
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (HL-60)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035009
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035009

GENE INFORMATION
Gene name	HRH4 (HGNC Symbol)
Synonyms	AXOR35, GPCR105, GPRv53, H4R, HH4R
Description	Histamine receptor H4 (HGNC Symbol)
Entrez gene summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	24460629 - 24479957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134489 (version 83.38)
Entrez gene	59340
UniProt	Q9H3N8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3N8
Antibodypedia	HRH4 antibodies

PROTEIN BROWSER

HRH4-001	HRH4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRH4-001 ENSP00000256906 ENST00000256906	Q9H3N8 [Direct mapping] Histamine H4 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007606 [sensory perception of chemical stimulus] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043408 [regulation of MAPK cascade] GO:0051381 [histamine binding] Show all	390 aa 44.5 kDa	No	7
HRH4-002 ENSP00000402526 ENST00000426880	Q9H3N8 [Direct mapping] Histamine H4 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007606 [sensory perception of chemical stimulus] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0043408 [regulation of MAPK cascade] GO:0051381 [histamine binding] Show all	302 aa 34.5 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.