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SOX3

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GENERAL INFORMATION

Gene name

 SOX3

Gene description

 SRY (sex determining region Y)-box 3

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Group enriched (NTERA-2, AF22, HEK 293)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA054720 , HPA075003
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (NTERA-2, AF22, HEK 293)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA054720 AF22 Nucleoplasm Intensity
HPA054720 HEK 293 Nucleoplasm
HPA054720 U-2 OS Nucleoplasm
HPA075003 AF22 Nucleoplasm Intensity
HPA075003 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 SOX3 (HGNC Symbol)

Synonyms

 PHP

Description

 SRY (sex determining region Y)-box 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q27.1

Chromosome location (bp)

 140502987 - 140505503

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134595 (version 83.38)

Entrez gene

 6658

UniProt

 P41225 (UniProt - Evidence at protein level)

neXtProt

 NX_P41225

Antibodypedia

 SOX3 antibodies

PROTEIN BROWSER
SOX3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX3-001
ENSP00000359567
ENST00000370536
P41225 [Direct mapping]
Transcription factor SOX-3
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007423 [sensory organ development]
GO:0007530 [sex determination]
GO:0009887 [organ morphogenesis]
GO:0021854 [hypothalamus development]
GO:0021983 [pituitary gland development]
GO:0030900 [forebrain development]
GO:0045665 [negative regulation of neuron differentiation]
GO:0048515 [spermatid differentiation]
GO:0048666 [neuron development]
GO:0060324 [face development]
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 446 aa
45.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.