Fields »
ABOUT
HELP
BLOG
MTNR1B

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MTNR1B

Gene description

 Melatonin receptor 1B

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MTNR1B

Synonyms

Description

 Melatonin receptor 1B (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q14.3

Chromosome location (bp)

 92969720 - 92985066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134640 (version 83.38)

Entrez gene

 4544

UniProt

 P49286 (UniProt - Evidence at protein level)

neXtProt

 NX_P49286

Antibodypedia

 MTNR1B antibodies

PROTEIN BROWSER
MTNR1B-001
MTNR1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTNR1B-001
ENSP00000257068
ENST00000257068
P49286 [Direct mapping]
Melatonin receptor type 1B
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007268 [synaptic transmission]
GO:0007623 [circadian rhythm]
GO:0008502 [melatonin receptor activity]
GO:0016021 [integral component of membrane]
GO:0030824 [negative regulation of cGMP metabolic process]
GO:0042593 [glucose homeostasis]
GO:0042753 [positive regulation of circadian rhythm]
GO:0043010 [camera-type eye development]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045909 [positive regulation of vasodilation]
GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0046676 [negative regulation of insulin secretion]
GO:0050796 [regulation of insulin secretion]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051970 [negative regulation of transmission of nerve impulse]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0098908 [regulation of neuronal action potential]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
Show all
 362 aa
40.2 kDa 		No 7
MTNR1B-003
ENSP00000433573
ENST00000528076
H0YDG4 [Direct mapping]
Melatonin receptor type 1B
Show all
Predicted intracellular proteins
Show all
 113 aa
12.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.