Tissue expression of MTNR1B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MTNR1B
Gene description	Melatonin receptor 1B
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	MTNR1B
Synonyms
Description	Melatonin receptor 1B (HGNC Symbol)
Entrez gene summary	This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q14.3
Chromosome location (bp)	92969720 - 92985066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134640 (version 83.38)
Entrez gene	4544
UniProt	P49286 (UniProt - Evidence at protein level)
neXtProt	NX_P49286
Antibodypedia	MTNR1B antibodies

PROTEIN BROWSER

MTNR1B-001	MTNR1B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTNR1B-001 ENSP00000257068 ENST00000257068	P49286 [Direct mapping] Melatonin receptor type 1B Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007268 [synaptic transmission] GO:0007623 [circadian rhythm] GO:0008502 [melatonin receptor activity] GO:0016021 [integral component of membrane] GO:0030824 [negative regulation of cGMP metabolic process] GO:0042593 [glucose homeostasis] GO:0042753 [positive regulation of circadian rhythm] GO:0043010 [camera-type eye development] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045909 [positive regulation of vasodilation] GO:0046010 [positive regulation of circadian sleep/wake cycle, non-REM sleep] GO:0046676 [negative regulation of insulin secretion] GO:0050796 [regulation of insulin secretion] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0051970 [negative regulation of transmission of nerve impulse] GO:0051971 [positive regulation of transmission of nerve impulse] GO:0098908 [regulation of neuronal action potential] GO:1902260 [negative regulation of delayed rectifier potassium channel activity] Show all	362 aa 40.2 kDa	No	7
MTNR1B-003 ENSP00000433573 ENST00000528076	H0YDG4 [Direct mapping] Melatonin receptor type 1B Show all	Predicted intracellular proteins Show all		113 aa 12.5 kDa	No	0