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CYP2J2

GENERAL INFORMATION

Gene name

 CYP2J2

Gene description

 Cytochrome P450, family 2, subfamily J, polypeptide 2

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (RT4, SK-BR-3)
HPA (normal tissue):Tissue enhanced (liver, small intestine)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CYP2J2

Synonyms

Description

 Cytochrome P450, family 2, subfamily J, polypeptide 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p32.1

Chromosome location (bp)

 59893308 - 59926790

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134716 (version 83.38)

Entrez gene

 1573

UniProt

 P51589 (UniProt - Evidence at protein level)

neXtProt

 NX_P51589

Antibodypedia

 CYP2J2 antibodies

PROTEIN BROWSER
CYP2J2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP2J2-001
ENSP00000360247
ENST00000371204
P51589 [Direct mapping]
Cytochrome P450 2J2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006690 [icosanoid metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008016 [regulation of heart contraction]
GO:0008392 [arachidonic acid epoxygenase activity]
GO:0008395 [steroid hydroxylase activity]
GO:0008404 [arachidonic acid 14,15-epoxygenase activity]
GO:0008405 [arachidonic acid 11,12-epoxygenase activity]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen]
GO:0019369 [arachidonic acid metabolic process]
GO:0019373 [epoxygenase P450 pathway]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0042738 [exogenous drug catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043651 [linoleic acid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070330 [aromatase activity]
GO:0071614 [linoleic acid epoxygenase activity]
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 502 aa
57.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.