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DSC2

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GENERAL INFORMATION

Gene name

 DSC2

Gene description

 Desmocollin 2

Protein class

 Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HaCaT, hTCEpi, CAPAN-2, BEWO)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, hTCEpi, CAPAN-2, BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DSC2 (HGNC Symbol)

Synonyms

 CDHF2, DSC3

Description

 Desmocollin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

 18

Cytoband

 q12.1

Chromosome location (bp)

 31058840 - 31102415

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134755 (version 83.38)

Entrez gene

 1824

UniProt

 Q02487 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02487

Antibodypedia

 DSC2 antibodies

PROTEIN BROWSER
DSC2-001
DSC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSC2-001
ENSP00000280904
ENST00000280904
Q02487 [Direct mapping]
Desmocollin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009267 [cellular response to starvation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030057 [desmosome]
GO:0031410 [cytoplasmic vesicle]
GO:0070062 [extracellular exosome]
GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 901 aa
100 kDa 		Yes 1
DSC2-002
ENSP00000251081
ENST00000251081
Q02487 [Direct mapping]
Desmocollin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030057 [desmosome]
GO:0031410 [cytoplasmic vesicle]
GO:0070062 [extracellular exosome]
GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 847 aa
93.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.