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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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DSC2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DSC2

Gene description

Desmocollin 2

Protein class

Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (BEWO, CAPAN-2, HaCaT, hTCEpi)
HPA (normal tissue):Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in squamous epithelia, gastrointestinal mucosa, pancreas, salivary glands, cytotrophoblasts and heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA011911 , HPA012615
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (unfavourable) and lung cancer (unfavourable).
Urothelial cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY

HPA011911
HPA012615

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed weak to moderate membranous immunoreactivity. A few cervical and endometrial cancers showed strong staining. Renal cancers, carcinoids, gliomas and lymphomas as well as most malignant melanomas, testicular and renal cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate cytoplasmic and membranous positivity. Colorectal cancers were mainly strongly stained. Gliomas, lymphomas and melanomas along with several cases of breast, testicular and renal cancers were weakly stained or negative

GENE INFORMATION

Gene name

DSC2 (HGNC Symbol)

Synonyms

CDHF2, DSC3

Description

Desmocollin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Chromosome

18

Cytoband

q12.1

Chromosome location (bp)

31058840 - 31102415

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134755 (version 83.38)

Entrez gene

1824

UniProt

Q02487 (UniProt - Evidence at protein level)

neXtProt

NX_Q02487

Antibodypedia

DSC2 antibodies

PROTEIN BROWSER

DSC2-001
DSC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DSC2-001
ENSP00000280904
ENST00000280904
Q02487 [Direct mapping]
Desmocollin-2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0009267 [cellular response to starvation]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030057 [desmosome]
GO:0031410 [cytoplasmic vesicle]
GO:0070062 [extracellular exosome]
GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
901 aa
100 kDa
Yes 1
DSC2-002
ENSP00000251081
ENST00000251081
Q02487 [Direct mapping]
Desmocollin-2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0014704 [intercalated disc]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030057 [desmosome]
GO:0031410 [cytoplasmic vesicle]
GO:0070062 [extracellular exosome]
GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
847 aa
93.8 kDa
Yes 1

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