Expression of TPGS2 in cancer - Summary - The Human Protein Atlas

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TPGS2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TPGS2
Gene description	Tubulin polyglutamylase complex subunit 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA040596 , HPA040617
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), ovarian cancer (favourable), cervical cancer (favourable) and testis cancer (favourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Cervical cancer p<0.001 Testis cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040596	HPA040617

GENE INFORMATION
Gene name	TPGS2 (HGNC Symbol)
Synonyms	C18orf10, DKFZP586M1523, HsT3006
Description	Tubulin polyglutamylase complex subunit 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	36777647 - 36829216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134779 (version 83.38)
Entrez gene	25941
UniProt	Q68CL5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q68CL5
Antibodypedia	TPGS2 antibodies

PROTEIN BROWSER

TPGS2-001	TPGS2-002	TPGS2-003	TPGS2-004	TPGS2-005	TPGS2-006	TPGS2-009	TPGS2-012	TPGS2-013	TPGS2-015	TPGS2-018	TPGS2-019	TPGS2-201	TPGS2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPGS2-001 ENSP00000335144 ENST00000334295	Q68CL5 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	300 aa 33.3 kDa	No	0
TPGS2-002 ENSP00000372530 ENST00000383056	Q68CL5 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	257 aa 28.7 kDa	No	0
TPGS2-003 ENSP00000467392 ENST00000593035	Q68CL5 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	265 aa 29.6 kDa	No	0
TPGS2-004 ENSP00000464780 ENST00000590842	Q68CL5 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	304 aa 34.4 kDa	No	0
TPGS2-005 ENSP00000466973 ENST00000589049	Q68CL5 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0005874 [microtubule] Show all	227 aa 25.7 kDa	No	0
TPGS2-006 ENSP00000467204 ENST00000587382	K7EP30 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		208 aa 23.5 kDa	No	0
TPGS2-009 ENSP00000465090 ENST00000588909	K7EJA6 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		43 aa 4.8 kDa	No	0
TPGS2-012 ENSP00000468292 ENST00000591906	K7ERK3 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		188 aa 21.2 kDa	No	0
TPGS2-013 ENSP00000482262 ENST00000590500	A0A087WZ07 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		163 aa 19 kDa	No	0
TPGS2-015 ENSP00000483592 ENST00000590258	A0A087X0Q8 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		59 aa 6.8 kDa	No	0
TPGS2-018 ENSP00000466788 ENST00000590337	K7EN50 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		119 aa 13.5 kDa	No	0
TPGS2-019 ENSP00000465551 ENST00000587129	K7EKC0 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		248 aa 27.8 kDa	No	0
TPGS2-201 ENSP00000484407 ENST00000610723	A0A087X1R7 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	Predicted intracellular proteins Show all		130 aa 14.5 kDa	No	0
TPGS2-202 ENSP00000478553 ENST00000614939	A0A087WUC8 [Direct mapping] Tubulin polyglutamylase complex subunit 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		232 aa 26.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.