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C5AR2

GENERAL INFORMATION

Gene name

 C5AR2

Gene description

 Complement component 5a receptor 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (breast cancer)
HPA (cell line):Group enriched (MCF7, T-47d)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA016629
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016629

GENE INFORMATION

Gene name

 C5AR2 (HGNC Symbol)

Synonyms

 C5L2, GPR77

Description

 Complement component 5a receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47332147 - 47347327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134830 (version 83.38)

Entrez gene

 27202

UniProt

 Q9P296 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P296

Antibodypedia

 C5AR2 antibodies

PROTEIN BROWSER
C5AR2-001
C5AR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C5AR2-001
ENSP00000472620
ENST00000595464
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
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 337 aa
36.1 kDa 		No 7
C5AR2-002
ENSP00000471184
ENST00000600626
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
 337 aa
36.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.