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Term
Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

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Method

Validation

Method

Validation

Method

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Specificity

Cell line

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Cancer

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Detectable

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Detectable

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Detectable

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Antibodies

Column

 
 
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C5AR2
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

C5AR2

Gene description

Complement component 5a receptor 2

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Uncertain based on 1 antibody.
HPA016629
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil)

GENE INFORMATION

Gene name

C5AR2 (HGNC Symbol)

Synonyms

C5L2, GPR77

Description

Complement component 5a receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

47332147 - 47347327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134830 (version 83.38)

Entrez gene

27202

UniProt

Q9P296 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P296

Antibodypedia

C5AR2 antibodies

PROTEIN BROWSER

C5AR2-001
C5AR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C5AR2-001
ENSP00000472620
ENST00000595464
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
337 aa
36.1 kDa
No 7
C5AR2-002
ENSP00000471184
ENST00000600626
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
337 aa
36.1 kDa
No 7

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