Fields »
ABOUT
HELP
BLOG
ADAMTS8

GENERAL INFORMATION

Gene name

 ADAMTS8

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 8

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (endometrial cancer)
HPA (cell line):Cell line enhanced (HMC-1, NTERA-2, U-2 OS)
HPA (normal tissue):Tissue enhanced (appendix, lung)

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Plasma positivity in most tissues including lung.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA066349
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA066349

GENE INFORMATION

Gene name

 ADAMTS8 (HGNC Symbol)

Synonyms

 ADAM-TS8, FLJ41712, METH2

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q24.3

Chromosome location (bp)

 130404925 - 130428993

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000134917 (version 83.38)

Entrez gene

 11095

UniProt

 Q9UP79 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UP79

Antibodypedia

 ADAMTS8 antibodies

PROTEIN BROWSER
ADAMTS8-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS8-001
ENSP00000257359
ENST00000257359
Q9UP79 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 8
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009673 [low-affinity phosphate transmembrane transporter activity]
GO:0031012 [extracellular matrix]
GO:0035435 [phosphate ion transmembrane transport]
Show all
 889 aa
96.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.