Tissue expression of ADAMTS8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADAMTS8
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 8
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (appendix, lung)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (gallbladder, lung)

Protein evidence

Evidence at transcript level

Protein expression

Plasma positivity in most tissues including lung.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA066349
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (appendix, lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder, lung)

GENE INFORMATION
Gene name	ADAMTS8 (HGNC Symbol)
Synonyms	ADAM-TS8, FLJ41712, METH2
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	130404925 - 130428993
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000134917 (version 83.38)
Entrez gene	11095
UniProt	Q9UP79 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UP79
Antibodypedia	ADAMTS8 antibodies

PROTEIN BROWSER

ADAMTS8-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS8-001 ENSP00000257359 ENST00000257359	Q9UP79 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 8 Show all	Enzymes Peptidases Metallopeptidases MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008201 [heparin binding] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0009673 [low-affinity phosphate transmembrane transporter activity] GO:0031012 [extracellular matrix] GO:0035435 [phosphate ion transmembrane transport] Show all	889 aa 96.5 kDa	Yes	0