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APC

GENERAL INFORMATION

Gene name

 APC

Gene description

 Adenomatous polyposis coli

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA013349 , CAB025994
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013349
CAB025994

GENE INFORMATION

Gene name

 APC (HGNC Symbol)

Synonyms

 DP2, DP2.5, DP3, PPP1R46

Description

 Adenomatous polyposis coli (HGNC Symbol)

Entrez gene summary

 This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q22.2

Chromosome location (bp)

 112707498 - 112846239

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134982 (version 83.38)

Entrez gene

 324

UniProt

 P25054 (UniProt - Evidence at protein level)

neXtProt

 NX_P25054

Antibodypedia

 APC antibodies

PROTEIN BROWSER
APC-001
APC-002
APC-004
APC-005
APC-008
APC-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APC-001
ENSP00000257430
ENST00000257430
P25054 [Direct mapping]
Adenomatous polyposis coli protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000776 [kinetochore]
GO:0001708 [cell fate specification]
GO:0001822 [kidney development]
GO:0001942 [hair follicle development]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005923 [bicellular tight junction]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0007091 [metaphase/anaphase transition of mitotic cell cycle]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007155 [cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007389 [pattern specification process]
GO:0007409 [axonogenesis]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0009798 [axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0012501 [programmed cell death]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019827 [stem cell population maintenance]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030877 [beta-catenin destruction complex]
GO:0031016 [pancreas development]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0031253 [cell projection membrane]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031965 [nuclear membrane]
GO:0032403 [protein complex binding]
GO:0032587 [ruffle membrane]
GO:0032886 [regulation of microtubule-based process]
GO:0033077 [T cell differentiation in thymus]
GO:0035019 [somatic stem cell population maintenance]
GO:0035371 [microtubule plus-end]
GO:0042483 [negative regulation of odontogenesis]
GO:0042493 [response to drug]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043588 [skin development]
GO:0044295 [axonal growth cone]
GO:0044306 [neuron projection terminus]
GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process]
GO:0044337 [canonical Wnt signaling pathway involved in positive regulation of apoptotic process]
GO:0045202 [synapse]
GO:0045295 [gamma-catenin binding]
GO:0045595 [regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045785 [positive regulation of cell adhesion]
GO:0046716 [muscle cell cellular homeostasis]
GO:0048538 [thymus development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051010 [microtubule plus-end binding]
GO:0051171 [regulation of nitrogen compound metabolic process]
GO:0051276 [chromosome organization]
GO:0051726 [regulation of cell cycle]
GO:0051781 [positive regulation of cell division]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060041 [retina development in camera-type eye]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
GO:0070830 [bicellular tight junction assembly]
GO:0070852 [cell body fiber]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097305 [response to alcohol]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2000211 [regulation of glutamate metabolic process]
Show all
 2843 aa
311.6 kDa 		No 0
APC-002
ENSP00000423224
ENST00000507379
B7Z2B6 [Direct mapping]
Adenomatous polyposis coli protein; cDNA FLJ50140, highly similar to Adenomatous polyposis coli protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0016477 [cell migration]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
Show all
 1135 aa
126.2 kDa 		No 0
APC-004
ENSP00000427089
ENST00000508376
P25054 [Direct mapping]
Adenomatous polyposis coli protein
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000776 [kinetochore]
GO:0001708 [cell fate specification]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005923 [bicellular tight junction]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007155 [cell adhesion]
GO:0007389 [pattern specification process]
GO:0008013 [beta-catenin binding]
GO:0008017 [microtubule binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0012501 [programmed cell death]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0016342 [catenin complex]
GO:0016477 [cell migration]
GO:0019887 [protein kinase regulator activity]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030335 [positive regulation of cell migration]
GO:0030877 [beta-catenin destruction complex]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0032587 [ruffle membrane]
GO:0032886 [regulation of microtubule-based process]
GO:0043065 [positive regulation of apoptotic process]
GO:0045295 [gamma-catenin binding]
GO:0045595 [regulation of cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0051010 [microtubule plus-end binding]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060070 [canonical Wnt signaling pathway]
GO:0070830 [bicellular tight junction assembly]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 2843 aa
311.6 kDa 		No 0
APC-005
ENSP00000423828
ENST00000512211
E9PFT7 [Direct mapping]
Adenomatous polyposis coli protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0016477 [cell migration]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
Show all
 1305 aa
145.8 kDa 		No 0
APC-008
ENSP00000426541
ENST00000509732
D6RFL6 [Direct mapping]
Adenomatous polyposis coli protein
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
Show all
 118 aa
13 kDa 		No 0
APC-011
ENSP00000473355
ENST00000504915
R4GMU6 [Direct mapping]
Adenomatous polyposis coli protein
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007050 [cell cycle arrest]
GO:0008013 [beta-catenin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016477 [cell migration]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
Show all
 272 aa
29.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.