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Most cancer cells showed weak to moderate cytoplasmic staining with occasional membranous immunoreactivity. A few prostate, ovarian, endometrial and pancreatic cancers were strongly stained. Colorectal cancers displayed additional membranous staining. Most lymphomas and several gliomas were negative.
GENE INFORMATION
Gene name
P2RX4 (HGNC Symbol)
Synonyms
P2X4
Description
Purinergic receptor P2X, ligand gated ion channel, 4 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]