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P2RX4
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

P2RX4

Gene description

Purinergic receptor P2X, ligand gated ion channel, 4

Protein class

Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and luminal membrane expression in most tissues, highly abundant in placental trophoblasts, lung macrophages and gastrointestinal mucosa.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA039494
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

P2RX4 (HGNC Symbol)

Synonyms

P2X4

Description

Purinergic receptor P2X, ligand gated ion channel, 4 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

121209857 - 121234106

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135124 (version 83.38)

Entrez gene

5025

UniProt

Q99571 (UniProt - Evidence at protein level)

neXtProt

NX_Q99571

Antibodypedia

P2RX4 antibodies

PROTEIN BROWSER

P2RX4-001
P2RX4-002
P2RX4-005
P2RX4-011
P2RX4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RX4-001
ENSP00000336607
ENST00000337233
Q99571 [Direct mapping]
P2X purinoceptor 4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0001894 [tissue homeostasis]
GO:0002028 [regulation of sodium ion transport]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005102 [receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010614 [negative regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034405 [response to fluid shear stress]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0042118 [endothelial cell activation]
GO:0042803 [protein homodimerization activity]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0051899 [membrane depolarization]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0055119 [relaxation of cardiac muscle]
GO:0070062 [extracellular exosome]
GO:0071318 [cellular response to ATP]
GO:0097190 [apoptotic signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
388 aa
43.4 kDa
No 2
P2RX4-002
ENSP00000353032
ENST00000359949
Q99571 [Direct mapping]
P2X purinoceptor 4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0001894 [tissue homeostasis]
GO:0002028 [regulation of sodium ion transport]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005102 [receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006809 [nitric oxide biosynthetic process]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0008144 [drug binding]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010614 [negative regulation of cardiac muscle hypertrophy]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034405 [response to fluid shear stress]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0042118 [endothelial cell activation]
GO:0042311 [vasodilation]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0051260 [protein homooligomerization]
GO:0051899 [membrane depolarization]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0055119 [relaxation of cardiac muscle]
GO:0060079 [excitatory postsynaptic potential]
GO:0070062 [extracellular exosome]
GO:0071318 [cellular response to ATP]
GO:0097190 [apoptotic signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
404 aa
45.3 kDa
No 2
P2RX4-005
ENSP00000438329
ENST00000542067
Q99571 [Direct mapping]
P2X purinoceptor 4
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0001894 [tissue homeostasis]
GO:0002028 [regulation of sodium ion transport]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005102 [receptor binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0008217 [regulation of blood pressure]
GO:0008270 [zinc ion binding]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010614 [negative regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0033198 [response to ATP]
GO:0034220 [ion transmembrane transport]
GO:0034405 [response to fluid shear stress]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0042118 [endothelial cell activation]
GO:0042803 [protein homodimerization activity]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0051899 [membrane depolarization]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0055119 [relaxation of cardiac muscle]
GO:0070062 [extracellular exosome]
GO:0071318 [cellular response to ATP]
GO:0097190 [apoptotic signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
361 aa
40.5 kDa
No 2
P2RX4-011
ENSP00000444033
ENST00000538701
F5H1M6 [Direct mapping]
P2X purinoceptor 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0033198 [response to ATP]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
145 aa
16.3 kDa
No 1
P2RX4-201
ENSP00000438131
ENST00000543171
F6SFZ6 [Direct mapping]
P2X purinoceptor 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001614 [purinergic nucleotide receptor activity]
GO:0004931 [extracellular ATP-gated cation channel activity]
GO:0005524 [ATP binding]
GO:0005639 [integral component of nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006812 [cation transport]
GO:0033198 [response to ATP]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0098655 [cation transmembrane transport]
Show all
341 aa
38 kDa
No 1

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