Expression of CSN2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CSN2
Gene description	Casein beta
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with additional plasma positivity in glandular cells of lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA041036
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041036

GENE INFORMATION
Gene name	CSN2 (HGNC Symbol)
Synonyms	CASB
Description	Casein beta (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	69955256 - 69961007
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135222 (version 83.38)
Entrez gene	1447
UniProt	P05814 (UniProt - Evidence at protein level)
neXtProt	NX_P05814
Antibodypedia	CSN2 antibodies

PROTEIN BROWSER

CSN2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSN2-001 ENSP00000341030 ENST00000353151	P05814 [Direct mapping] Beta-casein W5RWE1 [Target identity:100%; Query identity:100%] Beta-casein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004857 [enzyme inhibitor activity] GO:0005215 [transporter activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0007595 [lactation] GO:0043086 [negative regulation of catalytic activity] GO:1903488 [negative regulation of lactation] Show all	226 aa 25.4 kDa	Yes	0