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CSN2

GENERAL INFORMATION

Gene name

 CSN2

Gene description

 Casein beta

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (breast)
GTEx:Tissue enriched (breast)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with additional plasma positivity in glandular cells of lactating breast.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA041036
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Lactating breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (breast)

GENE INFORMATION

Gene name

 CSN2 (HGNC Symbol)

Synonyms

 CASB

Description

 Casein beta (HGNC Symbol)

Entrez gene summary

 This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 69955256 - 69961007

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135222 (version 83.38)

Entrez gene

 1447

UniProt

 P05814 (UniProt - Evidence at protein level)

neXtProt

 NX_P05814

Antibodypedia

 CSN2 antibodies

PROTEIN BROWSER
CSN2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSN2-001
ENSP00000341030
ENST00000353151
P05814 [Direct mapping]
Beta-casein
W5RWE1 [Target identity:100%; Query identity:100%]
Beta-casein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004857 [enzyme inhibitor activity]
GO:0005215 [transporter activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007595 [lactation]
GO:0043086 [negative regulation of catalytic activity]
GO:1903488 [negative regulation of lactation]
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 226 aa
25.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.