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Cancer tissues showed generally weak to moderate immunoreactivity. Gliomas, lymphomas and carcinoids as well as most testicular and urothelial cancers were negative.
GENE INFORMATION
Gene name
EPHA7 (HGNC Symbol)
Synonyms
Hek11
Description
EPH receptor A7 (HGNC Symbol)
Entrez gene summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]