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EPHA7

GENERAL INFORMATION

Gene name

 EPHA7

Gene description

 EPH receptor A7

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enhanced (colon)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB010496
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 EPHA7 (HGNC Symbol)

Synonyms

 Hek11

Description

 EPH receptor A7 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Chromosome

 6

Cytoband

 q16.1

Chromosome location (bp)

 93240020 - 93419547

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135333 (version 83.38)

Entrez gene

 2045

UniProt

 Q15375 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15375

Antibodypedia

 EPHA7 antibodies

PROTEIN BROWSER
EPHA7-001
EPHA7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHA7-001
ENSP00000358309
ENST00000369303
Q15375 [Direct mapping]
Ephrin type-A receptor 7
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008046 [axon guidance receptor activity]
GO:0016021 [integral component of membrane]
GO:0016310 [phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030425 [dendrite]
GO:0031290 [retinal ganglion cell axon guidance]
GO:0031594 [neuromuscular junction]
GO:0031952 [regulation of protein autophosphorylation]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045211 [postsynaptic membrane]
GO:0045499 [chemorepellent activity]
GO:0046875 [ephrin receptor binding]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048671 [negative regulation of collateral sprouting]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050919 [negative chemotaxis]
GO:0051964 [negative regulation of synapse assembly]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072178 [nephric duct morphogenesis]
Show all
 998 aa
112.1 kDa 		Yes 1
EPHA7-002
ENSP00000358303
ENST00000369297
Q15375 [Direct mapping]
Ephrin type-A receptor 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008046 [axon guidance receptor activity]
GO:0016021 [integral component of membrane]
GO:0016310 [phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0022407 [regulation of cell-cell adhesion]
GO:0031952 [regulation of protein autophosphorylation]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045499 [chemorepellent activity]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048755 [branching morphogenesis of a nerve]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050919 [negative chemotaxis]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
Show all
 279 aa
31.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.