Expression of CDK4 in cancer - Summary - The Human Protein Atlas

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CDK4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDK4
Gene description	Cyclin-dependent kinase 4
Protein class	Cancer-related genes Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (LHCN-M2, RH-30)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear and cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB069405
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB069405

GENE INFORMATION
Gene name	CDK4 (HGNC Symbol)
Synonyms	PSK-J3
Description	Cyclin-dependent kinase 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q14.1
Chromosome location (bp)	57747727 - 57756013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135446 (version 83.38)
Entrez gene	1019
UniProt	P11802 (UniProt - Evidence at protein level)
neXtProt	NX_P11802
Antibodypedia	CDK4 antibodies

PROTEIN BROWSER

CDK4-001	CDK4-004	CDK4-005	CDK4-006	CDK4-007	CDK4-009	CDK4-010	CDK4-011	CDK4-012	CDK4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK4-001 ENSP00000257904 ENST00000257904	P11802 [Direct mapping] Cyclin-dependent kinase 4 A0A024RBB6 [Target identity:100%; Query identity:100%] Cyclin-dependent kinase 4, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000785 [chromatin] GO:0002088 [lens development in camera-type eye] GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005923 [bicellular tight junction] GO:0006325 [chromatin organization] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010288 [response to lead ion] GO:0010468 [regulation of gene expression] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0016301 [kinase activity] GO:0016538 [cyclin-dependent protein serine/threonine kinase regulator activity] GO:0030332 [cyclin binding] GO:0031100 [organ regeneration] GO:0031965 [nuclear membrane] GO:0032403 [protein complex binding] GO:0033574 [response to testosterone] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0045727 [positive regulation of translation] GO:0045793 [positive regulation of cell size] GO:0045859 [regulation of protein kinase activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia] GO:0071157 [negative regulation of cell cycle arrest] Show all	303 aa 33.7 kDa	No	0
CDK4-004 ENSP00000447005 ENST00000549606	F8VZ13 [Direct mapping] Cyclin-dependent kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.6 kDa	No	0
CDK4-005 ENSP00000449391 ENST00000551800	F8VXD2 [Direct mapping] Cyclin-dependent kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	132 aa 14.9 kDa	No	0
CDK4-006 ENSP00000448963 ENST00000552388	F8VYH9 [Direct mapping] Cyclin-dependent kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	170 aa 18.7 kDa	No	0
CDK4-007 ENSP00000447779 ENST00000546489	F8VZ51 [Direct mapping] Cyclin-dependent kinase 4 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	208 aa 23.5 kDa	No	0
CDK4-009 ENSP00000447274 ENST00000547281	F8VZZ0 [Direct mapping] Cyclin-dependent kinase 4 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	186 aa 21 kDa	No	0
CDK4-010 ENSP00000449725 ENST00000547853		Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all		2 aa 0.2 kDa	No	0
CDK4-011 ENSP00000449179 ENST00000552254	F8VWX7 [Direct mapping] Cyclin-dependent kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	203 aa 22.4 kDa	No	0
CDK4-012 ENSP00000446763 ENST00000552862	F8W1L8 [Direct mapping] Cyclin-dependent kinase 4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	115 aa 12.5 kDa	No	0
CDK4-201 ENSP00000316889 ENST00000312990	Q96BE9 [Direct mapping] CDK4 protein; Cyclin-dependent kinase 4; Cyclin-dependent kinase 4, isoform CRA_c Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	111 aa 12 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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