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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MIP
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MIP

Gene description

Major intrinsic protein of lens fiber

Protein class

Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the lens.

ANTIBODY IHC RELIABILITY

Data reliability
description

External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

Supported based on 1 antibody.
HPA014940
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA014940

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

MIP (HGNC Symbol)

Synonyms

AQP0, LIM1, MP26

Description

Major intrinsic protein of lens fiber (HGNC Symbol)

Entrez gene summary

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.3

Chromosome location (bp)

56449502 - 56469166

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135517 (version 83.38)

Entrez gene

4284

UniProt

P30301 (UniProt - Evidence at protein level)

neXtProt

NX_P30301

Antibodypedia

MIP antibodies

PROTEIN BROWSER

MIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MIP-001
ENSP00000257979
ENST00000257979
P30301 [Direct mapping]
Lens fiber major intrinsic protein
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Show all
GO:0002088 [lens development in camera-type eye]
GO:0005212 [structural constituent of eye lens]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005921 [gap junction]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007601 [visual perception]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015722 [canalicular bile acid transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046691 [intracellular canaliculus]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
Show all
263 aa
28.1 kDa
No 6

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