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MIP

GENERAL INFORMATION

Gene name

 MIP

Gene description

 Major intrinsic protein of lens fiber

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Highly expressed in the lens.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA014940
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Eye
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Eye

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 MIP (HGNC Symbol)

Synonyms

 AQP0, LIM1, MP26

Description

 Major intrinsic protein of lens fiber (HGNC Symbol)

Entrez gene summary

 Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56449502 - 56469166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135517 (version 83.38)

Entrez gene

 4284

UniProt

 P30301 (UniProt - Evidence at protein level)

neXtProt

 NX_P30301

Antibodypedia

 MIP antibodies

PROTEIN BROWSER
MIP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIP-001
ENSP00000257979
ENST00000257979
P30301 [Direct mapping]
Lens fiber major intrinsic protein
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
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GO:0002088 [lens development in camera-type eye]
GO:0005212 [structural constituent of eye lens]
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005921 [gap junction]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0007601 [visual perception]
GO:0009992 [cellular water homeostasis]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015722 [canalicular bile acid transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046691 [intracellular canaliculus]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
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 263 aa
28.1 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.