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MICAL1

GENERAL INFORMATION

Gene name

 MICAL1

Gene description

 Microtubule associated monooxygenase, calponin and LIM domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (THP-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA030175 , HPA030176 , HPA030178
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030175
HPA030176
HPA030178

GENE INFORMATION

Gene name

 MICAL1 (HGNC Symbol)

Synonyms

 DKFZp434B1517, FLJ11937, FLJ21739, MICAL, NICAL

Description

 Microtubule associated monooxygenase, calponin and LIM domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 109444062 - 109465968

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135596 (version 83.38)

Entrez gene

 64780

UniProt

 Q8TDZ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDZ2

Antibodypedia

 MICAL1 antibodies

PROTEIN BROWSER
MICAL1-001
MICAL1-002
MICAL1-006
MICAL1-007
MICAL1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MICAL1-001
ENSP00000351664
ENST00000358807
Q8TDZ2 [Direct mapping]
Protein-methionine sulfoxide oxidase MICAL1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0017124 [SH3 domain binding]
GO:0019417 [sulfur oxidation]
GO:0030042 [actin filament depolymerization]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 1067 aa
117.9 kDa 		No 0
MICAL1-002
ENSP00000408924
ENST00000433205
H0Y6Z4 [Direct mapping]
Protein-methionine sulfoxide oxidase MICAL1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 252 aa
27.1 kDa 		No 0
MICAL1-006
ENSP00000407075
ENST00000431946
Q5TED7 [Direct mapping]
Protein-methionine sulfoxide oxidase MICAL1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0071949 [FAD binding]
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 244 aa
26.8 kDa 		No 0
MICAL1-007
ENSP00000486901
ENST00000630715
Q8TDZ2 [Direct mapping]
Protein-methionine sulfoxide oxidase MICAL1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001933 [negative regulation of protein phosphorylation]
GO:0003779 [actin binding]
GO:0004497 [monooxygenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0017124 [SH3 domain binding]
GO:0017137 [Rab GTPase binding]
GO:0019417 [sulfur oxidation]
GO:0030042 [actin filament depolymerization]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
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 1086 aa
119.8 kDa 		No 0
MICAL1-008
ENSP00000351385
ENST00000358577
Q8TDZ2 [Direct mapping]
Protein-methionine sulfoxide oxidase MICAL1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen]
GO:0017124 [SH3 domain binding]
GO:0019417 [sulfur oxidation]
GO:0030042 [actin filament depolymerization]
GO:0055114 [oxidation-reduction process]
GO:0071949 [FAD binding]
Show all
 981 aa
108.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.