Expression of KCNK1 in cancer - Summary

GENERAL INFORMATION
Gene name	KCNK1
Gene description	Potassium channel, two pore domain subfamily K, member 1
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H, U-266/70, U-266/84)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression at variable levels. High levels in brain and glandular epithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA016049 , CAB022588
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA016049	CAB022588

GENE INFORMATION
Gene name	KCNK1 (HGNC Symbol)
Synonyms	DPK, K2p1.1, TWIK-1
Description	Potassium channel, two pore domain subfamily K, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	233614004 - 233672512
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135750 (version 83.38)
Entrez gene	3775
UniProt	O00180 (UniProt - Evidence at protein level)
neXtProt	NX_O00180
Antibodypedia	KCNK1 antibodies

PROTEIN BROWSER

KCNK1-001	KCNK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK1-001 ENSP00000355580 ENST00000366621	O00180 [Direct mapping] Potassium channel subfamily K member 1 A0A024R3T2 [Target identity:100%; Query identity:100%] Potassium channel, subfamily K, member 1, isoform CRA_a Show all	Voltage-gated ion channels Two-P Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005242 [inward rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005272 [sodium channel activity] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016324 [apical plasma membrane] GO:0022841 [potassium ion leak channel activity] GO:0030054 [cell junction] GO:0030322 [stabilization of membrane potential] GO:0030425 [dendrite] GO:0031526 [brush border membrane] GO:0034705 [potassium channel complex] GO:0035094 [response to nicotine] GO:0035725 [sodium ion transmembrane transport] GO:0043204 [perikaryon] GO:0045202 [synapse] GO:0055037 [recycling endosome] GO:0060075 [regulation of resting membrane potential] GO:0071805 [potassium ion transmembrane transport] GO:1902937 [inward rectifier potassium channel complex] Show all	336 aa 38.1 kDa	No	6
KCNK1-006 ENSP00000409626 ENST00000446915	Q5T5E6 [Direct mapping] Potassium channel subfamily K member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	242 aa 27.5 kDa	No	4