Expression of COG2 in cancer - Summary - The Human Protein Atlas

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COG2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	COG2
Gene description	Component of oligomeric golgi complex 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	COG2 (HGNC Symbol)
Synonyms	LDLC
Description	Component of oligomeric golgi complex 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	230642489 - 230693982
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135775 (version 83.38)
Entrez gene	22796
UniProt	Q14746 (UniProt - Evidence at protein level)
neXtProt	NX_Q14746
Antibodypedia	COG2 antibodies

PROTEIN BROWSER

COG2-001	COG2-002	COG2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COG2-001 ENSP00000355629 ENST00000366669	Q14746 [Direct mapping] Conserved oligomeric Golgi complex subunit 2 B1ALW7 [Target identity:100%; Query identity:100%] Component of oligomeric golgi complex 2, isoform CRA_a; cDNA, FLJ93071, Homo sapiens component of oligomeric golgi complex 2 (COG2), mRNA Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005795 [Golgi stack] GO:0005829 [cytosol] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0007030 [Golgi organization] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0017119 [Golgi transport complex] GO:0032403 [protein complex binding] Show all	738 aa 83.2 kDa	No	0
COG2-002 ENSP00000355628 ENST00000366668	Q14746 [Direct mapping] Conserved oligomeric Golgi complex subunit 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005795 [Golgi stack] GO:0006891 [intra-Golgi vesicle-mediated transport] GO:0007030 [Golgi organization] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0017119 [Golgi transport complex] Show all	737 aa 83.1 kDa	No	0
COG2-010 ENSP00000440349 ENST00000534989	B7Z2Y2 [Direct mapping] Conserved oligomeric Golgi complex subunit 2; cDNA FLJ55945, highly similar to Conserved oligomeric Golgi complex component 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007030 [Golgi organization] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	679 aa 76.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.