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COG2

GENERAL INFORMATION

Gene name

 COG2

Gene description

 Component of oligomeric golgi complex 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin02468101214RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

 COG2 (HGNC Symbol)

Synonyms

 LDLC

Description

 Component of oligomeric golgi complex 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

Chromosome

 1

Cytoband

 q42.2

Chromosome location (bp)

 230642489 - 230693982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135775 (version 83.38)

Entrez gene

 22796

UniProt

 Q14746 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14746

Antibodypedia

 COG2 antibodies

PROTEIN BROWSER
COG2-001
COG2-002
COG2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COG2-001
ENSP00000355629
ENST00000366669
Q14746 [Direct mapping]
Conserved oligomeric Golgi complex subunit 2
B1ALW7 [Target identity:100%; Query identity:100%]
Component of oligomeric golgi complex 2, isoform CRA_a; cDNA, FLJ93071, Homo sapiens component of oligomeric golgi complex 2 (COG2), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005795 [Golgi stack]
GO:0005829 [cytosol]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0007030 [Golgi organization]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0017119 [Golgi transport complex]
GO:0032403 [protein complex binding]
Show all
 738 aa
83.2 kDa 		No 0
COG2-002
ENSP00000355628
ENST00000366668
Q14746 [Direct mapping]
Conserved oligomeric Golgi complex subunit 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005795 [Golgi stack]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0007030 [Golgi organization]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0017119 [Golgi transport complex]
Show all
 737 aa
83.1 kDa 		No 0
COG2-010
ENSP00000440349
ENST00000534989
B7Z2Y2 [Direct mapping]
Conserved oligomeric Golgi complex subunit 2; cDNA FLJ55945, highly similar to Conserved oligomeric Golgi complex component 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007030 [Golgi organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 679 aa
76.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.