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Cancer tissues expressed moderate to strong cytoplasmic. Renal cancers displayed a distinct membranous staining pattern.
GENE INFORMATION
Gene name
RNASEL (HGNC Symbol)
Synonyms
PRCA1, RNS4
Description
Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (HGNC Symbol)
Entrez gene summary
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]