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RNASEL

GENERAL INFORMATION

Gene name

 RNASEL

Gene description

 Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA002633 , CAB010906
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 RNASEL (HGNC Symbol)

Synonyms

 PRCA1, RNS4

Description

 Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 182573634 - 182589256

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135828 (version 83.38)

Entrez gene

 6041

UniProt

 Q05823 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05823

Antibodypedia

 RNASEL antibodies

PROTEIN BROWSER
RNASEL-001
RNASEL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASEL-001
ENSP00000356530
ENST00000367559
Q05823 [Direct mapping]
2-5A-dependent ribonuclease
Show all
Enzymes
   Kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0016363 [nuclear matrix]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019843 [rRNA binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043488 [regulation of mRNA stability]
GO:0045071 [negative regulation of viral genome replication]
GO:0045444 [fat cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0055085 [transmembrane transport]
GO:0060337 [type I interferon signaling pathway]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
 741 aa
83.5 kDa 		No 0
RNASEL-201
ENSP00000440844
ENST00000539397
Q05823 [Direct mapping]
2-5A-dependent ribonuclease
Show all
Enzymes
   Kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045071 [negative regulation of viral genome replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0055085 [transmembrane transport]
GO:0060337 [type I interferon signaling pathway]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 652 aa
73.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.