Expression of PIGC in cancer - Summary - The Human Protein Atlas

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PIGC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PIGC
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class C
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036663
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036663

GENE INFORMATION
Gene name	PIGC
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class C (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.3
Chromosome location (bp)	172370189 - 172444086
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135845 (version 83.38)
Entrez gene	5279
UniProt	Q92535 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92535
Antibodypedia	PIGC antibodies

PROTEIN BROWSER

PIGC-001	PIGC-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGC-001 ENSP00000356701 ENST00000344529	Q92535 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	297 aa 33.6 kDa	No	7
PIGC-004 ENSP00000356702 ENST00000367728	Q92535 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	297 aa 33.6 kDa	No	7

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.