Tissue expression of PIGC - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PIGC

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PIGC
Gene description	Phosphatidylinositol glycan anchor biosynthesis, class C
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membranous and cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA036663
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PIGC
Synonyms
Description	Phosphatidylinositol glycan anchor biosynthesis, class C (HGNC Symbol)
Entrez gene summary	This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.3
Chromosome location (bp)	172370189 - 172444086
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135845 (version 83.38)
Entrez gene	5279
UniProt	Q92535 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92535
Antibodypedia	PIGC antibodies

PROTEIN BROWSER

PIGC-001	PIGC-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PIGC-001 ENSP00000356701 ENST00000344529	Q92535 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	297 aa 33.6 kDa	No	7
PIGC-004 ENSP00000356702 ENST00000367728	Q92535 [Direct mapping] Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000506 [glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex] GO:0003824 [catalytic activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006501 [C-terminal protein lipidation] GO:0006506 [GPI anchor biosynthetic process] GO:0016021 [integral component of membrane] GO:0016254 [preassembly of GPI anchor in ER membrane] GO:0017176 [phosphatidylinositol N-acetylglucosaminyltransferase activity] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	297 aa 33.6 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.