Expression of SP110 in cancer - Summary - The Human Protein Atlas

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SP110

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SP110
Gene description	SP110 nuclear body protein
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Cytoplasmic positivity observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA047036
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047036

GENE INFORMATION
Gene name	SP110 (HGNC Symbol)
Synonyms	IFI41, IFI75
Description	SP110 nuclear body protein (HGNC Symbol)
Entrez gene summary	The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	230167293 - 230225729
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135899 (version 83.38)
Entrez gene	3431
UniProt	Q9HB58 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB58
Antibodypedia	SP110 antibodies

PROTEIN BROWSER

SP110-001	SP110-002	SP110-003	SP110-004	SP110-006	SP110-007	SP110-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP110-001 ENSP00000258382 ENST00000258382	Q9HB58 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Plasma proteins Transcription factors alpha-Helices exposed by beta-structures Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0016032 [viral process] Show all	549 aa 61.9 kDa	No	0
SP110-002 ENSP00000258381 ENST00000258381	Q9HB58 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Plasma proteins Transcription factors alpha-Helices exposed by beta-structures Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0016032 [viral process] Show all	713 aa 81.2 kDa	No	0
SP110-003 ENSP00000351488 ENST00000358662	Q9HB58 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Plasma proteins Transcription factors alpha-Helices exposed by beta-structures Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0016032 [viral process] Show all	689 aa 78.4 kDa	No	0
SP110-004 ENSP00000375902 ENST00000392048	G5E9C0 [Direct mapping] SP110 nuclear body protein, isoform CRA_b; Sp110 nuclear body protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	547 aa 61.7 kDa	No	0
SP110-006 ENSP00000399978 ENST00000416610	E9PHK4 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	101 aa 12 kDa	No	0
SP110-007 ENSP00000387172 ENST00000409815	E7EM70 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	221 aa 24.6 kDa	No	0
SP110-008 ENSP00000393992 ENST00000455674	C9JZQ4 [Direct mapping] Sp110 nuclear body protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] Show all	160 aa 17.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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