Fields »
ABOUT
HELP
BLOG
SP110

GENERAL INFORMATION

Gene name

 SP110

Gene description

 SP110 nuclear body protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Cytoplasmic positivity observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA047036
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SP110 (HGNC Symbol)

Synonyms

 IFI41, IFI75

Description

 SP110 nuclear body protein (HGNC Symbol)

Entrez gene summary

 The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 230167293 - 230225729

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135899 (version 83.38)

Entrez gene

 3431

UniProt

 Q9HB58 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HB58

Antibodypedia

 SP110 antibodies

PROTEIN BROWSER
SP110-001
SP110-002
SP110-003
SP110-004
SP110-006
SP110-007
SP110-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SP110-001
ENSP00000258382
ENST00000258382
Q9HB58 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
Show all
 549 aa
61.9 kDa 		No 0
SP110-002
ENSP00000258381
ENST00000258381
Q9HB58 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
Show all
 713 aa
81.2 kDa 		No 0
SP110-003
ENSP00000351488
ENST00000358662
Q9HB58 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016032 [viral process]
Show all
 689 aa
78.4 kDa 		No 0
SP110-004
ENSP00000375902
ENST00000392048
G5E9C0 [Direct mapping]
SP110 nuclear body protein, isoform CRA_b; Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 547 aa
61.7 kDa 		No 0
SP110-006
ENSP00000399978
ENST00000416610
E9PHK4 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 101 aa
12 kDa 		No 0
SP110-007
ENSP00000387172
ENST00000409815
E7EM70 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 221 aa
24.6 kDa 		No 0
SP110-008
ENSP00000393992
ENST00000455674
C9JZQ4 [Direct mapping]
Sp110 nuclear body protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 160 aa
17.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.