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HTR2B

GENERAL INFORMATION

Gene name

 HTR2B

Gene description

 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine, endometrium, smooth muscle)
GTEx:Tissue enhanced (adrenal gland, endometrium)
FANTOM5:Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA012867 , CAB011448
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine, endometrium, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, endometrium)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION

Gene name

 HTR2B (HGNC Symbol)

Synonyms

 5-HT(2B), 5-HT2B

Description

 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 231108230 - 231125118

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135914 (version 83.38)

Entrez gene

 3357

UniProt

 P41595 (UniProt - Evidence at protein level)

neXtProt

 NX_P41595

Antibodypedia

 HTR2B antibodies

PROTEIN BROWSER
HTR2B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR2B-001
ENSP00000258400
ENST00000258400
P41595 [Direct mapping]
5-hydroxytryptamine receptor 2B
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0001755 [neural crest cell migration]
GO:0001819 [positive regulation of cytokine production]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001965 [G-protein alpha-subunit binding]
GO:0002031 [G-protein coupled receptor internalization]
GO:0003007 [heart morphogenesis]
GO:0003300 [cardiac muscle hypertrophy]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007210 [serotonin receptor signaling pathway]
GO:0007507 [heart development]
GO:0007610 [behavior]
GO:0008144 [drug binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0010513 [positive regulation of phosphatidylinositol biosynthetic process]
GO:0014033 [neural crest cell differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014827 [intestine smooth muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016310 [phosphorylation]
GO:0019722 [calcium-mediated signaling]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0034220 [ion transmembrane transport]
GO:0035733 [hepatic stellate cell activation]
GO:0042310 [vasoconstriction]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0045202 [synapse]
GO:0048598 [embryonic morphogenesis]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050795 [regulation of behavior]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051378 [serotonin binding]
GO:0051781 [positive regulation of cell division]
GO:0060548 [negative regulation of cell death]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070528 [protein kinase C signaling]
GO:0071418 [cellular response to amine stimulus]
GO:0071502 [cellular response to temperature stimulus]
GO:1904015 [cellular response to serotonin]
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 481 aa
54.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.