Expression of STAB2 in cancer - Summary

GENERAL INFORMATION
Gene name	STAB2
Gene description	Stabilin 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (BEWO, HaCaT)
HPA (normal tissue):	Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in sinusoidal endothelial cells of liver, spleen and lymph node.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA026871
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA026871

GENE INFORMATION
Gene name	STAB2 (HGNC Symbol)
Synonyms	DKFZP434E0321, FEEL-2, FELL, HARE, STAB-2
Description	Stabilin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	103587273 - 103766727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136011 (version 83.38)
Entrez gene	55576
UniProt	Q8WWQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWQ8
Antibodypedia	STAB2 antibodies

PROTEIN BROWSER

STAB2-001	STAB2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAB2-001 ENSP00000373539 ENST00000388887	Q8WWQ8 [Direct mapping] Stabilin-2 190 kDa form stabilin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005041 [low-density lipoprotein receptor activity] GO:0005044 [scavenger receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0009897 [external side of plasma membrane] GO:0010468 [regulation of gene expression] GO:0015035 [protein disulfide oxidoreductase activity] GO:0030169 [low-density lipoprotein particle binding] GO:0030193 [regulation of blood coagulation] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030214 [hyaluronan catabolic process] GO:0030666 [endocytic vesicle membrane] GO:0042742 [defense response to bacterium] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	2551 aa 277 kDa	Yes	1
STAB2-006 ENSP00000446629 ENST00000552777	H0YHA5 [Direct mapping] Stabilin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.6 kDa	No	0